adipose tissue remodeling and obesity definition
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adipose tissue remodeling and obesity definition
(PDF) Adipose tissue remodeling and obesity- adipose tissue remodeling and obesity definition ,Adipose tissue remodeling and obesity Kai Sun, 1 Christine M. Kusminski, 1 and Philipp E. Scherer 1,2 1 Touchstone Diabetes Center , Department of Internal Medicine, and 2 …Adipose tissue remodeling and obesity. - Abstract - Europe PMCJun 01, 2011·Adipose tissue remodeling and obesity. Kai Sun Touchstone Diabetes Center, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390-8549, USA.
Browning Epicardial Adipose Tissue: Friend or Foe?
The epicardial adipose tissue (EAT) is the visceral fat depot of the heart which is highly plastic and in direct contact with myocardium and coronary arteries. Because of its singular proximity with the myocardium, the adipokines and pro-inflammatory molecules secreted by this tissue may directly affect the metabolism of the heart and coronary arteries.
Adipose tissue remodeling in pathophysiology of obesity
Purpose of review: Recent studies demonstrate that adipose tissue undergoes a continuous process of remodeling that is pathologically accelerated in the obese state. Contrary to earlier dogma, adipocytes die and are replaced by newly differentiated ones. This review will summarize recent advances of our knowledge of the mechanisms that regulate adipose tissue …
Metabolic remodeling of white adipose tissue in obesity
May 15, 2013·Adipose tissue metabolite profiling. WAT from the epididymal fat pads of mice fed LFD or HFD for 6 wk was used for these analyses. Prior to tissue collection, the mice were fasted for 16 h. After euthanization, the adipose tissue was removed and immediately snap-frozen in liquid nitrogen. Relative metabolite abundance was then
Adipose tissue remodeling and obesity
AT remodeling is an ongoing process that is pathologically accelerated in the obese state, and thus, fea- tures such as reduced angiogenic remodeling, ECM overproduc- tion, a heightened state of immune cell infiltration and subsequent proinflammatory responses prevail in many obese fat-pads (1).
Adipose tissue remodeling and obesity - PubMed
Adipose tissue remodeling and obesity J Clin Invest. 2011 Jun;121(6):2094-101. doi: 10.1172/JCI45887. Epub 2011 Jun 1. Authors Kai Sun 1 , Christine M Kusminski, Philipp E Scherer. Affiliation 1 Touchstone Diabetes Center, Department of ...
Adipose tissue remodeling and obesity
Jun 01, 2011·Adipose tissue remodeling and obesity. Kai Sun, 1 Christine M. Kusminski, 1 and Philipp E. Scherer 1, 2 ... To fulfill its role as the major energy-storing tissue, adipose has several unique properties that cannot be seen in any other organ, including an almost unlimited capacity to expand in a non-transformed state. ... delineating an ...
Adipose tissue remodeling in pathophysiology of obesity
Purpose of review: Recent studies demonstrate that adipose tissue undergoes a continuous process of remodeling that is pathologically accelerated in the obese state. Contrary to earlier dogma, adipocytes die and are replaced by newly differentiated ones. This review will summarize recent advances of our knowledge of the mechanisms that regulate adipose tissue …
Adipose Tissue Dysfunction as Determinant of Obesity ...
Apr 30, 2019·2. Adipose Tissue Remodeling in Obesity The adipose tissue has a crucial role in the regulation of systemic energy homeostasis acting as a “safe” depot to store excess fat. In overnutrition, mature adipocytes accumulate more fat and undergo cellular hypertrophy [24], whereas during calorie restriction they provide nutrients to other tissues
Obesity, Adipose Tissue and Vascular Dysfunction ...
Massive expansion and remodeling of adipose tissue during obesity differentially affects specific adipose tissue depots and significantly contributes to vascular dysfunction and cardiovascular diseases. Visceral adipose tissue accumulation results in increased immune cell infiltration and secretion of vasoconstrictor mediators, whereas ...
(PDF) Adipose tissue remodeling and obesity
Adipose ti ssue (AT) can respond rapidly and dynamicall y to altera tions in nutrient depriv ation and excess through ad ipocyte hyper trophy and …
Adipocyte Death, Adipose Tissue Remodeling, and Obesity ...
Dec 01, 2007·Adipose tissue (AT) macrophages (ATMΦs) promote obesity-associated AT inflammation and insulin resistance (1–5).Infiltrating ATMΦs secrete proinflammatory mediators that are elevated in AT of obese mice and humans and are implicated in the development of insulin resistance, including tumor necrosis factor (TNF)-α, interleukin (IL)-6, and monocyte …
Metabolic remodeling of white adipose tissue in obesity
Aug 01, 2014·Adipose tissue metabolism is a critical regulator of adiposity and whole body energy expenditure; however, metabolic changes that occur in white adipose tissue (WAT) with obesity remain unclear. The purpose of this study was to understand the metabolic and bioenergetic changes occurring in WAT with obesity.
Adipose tissue remodeling and obesity
Jun 01, 2011·Adipose tissue remodeling and obesity. Kai Sun, 1 Christine M. Kusminski, 1 and Philipp E. Scherer 1, 2 ... To fulfill its role as the major energy-storing tissue, adipose has several unique properties that cannot be seen in any other organ, including an almost unlimited capacity to expand in a non-transformed state. ... delineating an ...
Browning Epicardial Adipose Tissue: Friend or Foe?
The epicardial adipose tissue (EAT) is the visceral fat depot of the heart which is highly plastic and in direct contact with myocardium and coronary arteries. Because of its singular proximity with the myocardium, the adipokines and pro-inflammatory molecules secreted by this tissue may directly affect the metabolism of the heart and coronary arteries.
Adipose tissue remodeling and obesity. - Abstract - Europe PMC
Jun 01, 2011·Adipose tissue remodeling and obesity. Kai Sun Touchstone Diabetes Center, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390-8549, USA.
Browning Epicardial Adipose Tissue: Friend or Foe?
The epicardial adipose tissue (EAT) is the visceral fat depot of the heart which is highly plastic and in direct contact with myocardium and coronary arteries. Because of its singular proximity with the myocardium, the adipokines and pro-inflammatory molecules secreted by this tissue may directly affect the metabolism of the heart and coronary arteries.
(PDF) Adipose tissue remodeling and obesity
Adipose tissue remodeling and obesity Kai Sun, 1 Christine M. Kusminski, 1 and Philipp E. Scherer 1,2 1 Touchstone Diabetes Center , Department of Internal Medicine, and 2 …
Adipose Tissue Remodeling | Ruan Laboratory
Brown adipose tissue development & involution. Obesity is a global epidemic. The excessive fat accumulation in white adipose tissue (WAT) and visceral organs is a major risk factor for many diseases, including type 2 diabetes, hypertension, heart disease, and some types of cancers.
Metabolic remodeling of white adipose tissue in obesity
May 15, 2013·Adipose tissue metabolite profiling. WAT from the epididymal fat pads of mice fed LFD or HFD for 6 wk was used for these analyses. Prior to tissue collection, the mice were fasted for 16 h. After euthanization, the adipose tissue was removed and immediately snap-frozen in liquid nitrogen. Relative metabolite abundance was then
Adipose tissue remodeling and obesity - PubMed
Adipose tissue remodeling and obesity J Clin Invest. 2011 Jun;121(6):2094-101. doi: 10.1172/JCI45887. Epub 2011 Jun 1. Authors Kai Sun 1 , Christine M Kusminski, Philipp E Scherer. Affiliation 1 Touchstone Diabetes Center, Department of ...
Adipocyte Death, Adipose Tissue Remodeling, and Obesity ...
Dec 01, 2007·Adipose tissue (AT) macrophages (ATMΦs) promote obesity-associated AT inflammation and insulin resistance (1–5).Infiltrating ATMΦs secrete proinflammatory mediators that are elevated in AT of obese mice and humans and are implicated in the development of insulin resistance, including tumor necrosis factor (TNF)-α, interleukin (IL)-6, and monocyte …
Adipose Tissue Dysfunction as Determinant of Obesity ...
Apr 30, 2019·2. Adipose Tissue Remodeling in Obesity The adipose tissue has a crucial role in the regulation of systemic energy homeostasis acting as a “safe” depot to store excess fat. In overnutrition, mature adipocytes accumulate more fat and undergo cellular hypertrophy [24], whereas during calorie restriction they provide nutrients to other tissues
Obesity, Adipose Tissue and Vascular Dysfunction ...
Massive expansion and remodeling of adipose tissue during obesity differentially affects specific adipose tissue depots and significantly contributes to vascular dysfunction and cardiovascular diseases. Visceral adipose tissue accumulation results in increased immune cell infiltration and secretion of vasoconstrictor mediators, whereas ...
JCI - Adipose tissue remodeling and obesity
Jun 01, 2011·Adipose tissue remodeling and obesity. Text. PDF. Abstract. To fulfill its role as the major energy-storing tissue, adipose has several unique properties that cannot be seen in any other organ, including an almost unlimited capacity to expand in a non-transformed state. As such, the tissue requires potent mechanisms to remodel, acutely and ...